Rollero A, Murialdo G, Fonzi S, Garrone S, Gianelli M V, Gazzerro E, Barreca A, Polleri A
Department of Endocrinological and Metabolic Sciences, University of Genova, Italy.
Neuropsychobiology. 1998;38(2):73-9. doi: 10.1159/000026520.
Basal growth hormone (GH) and insulin-like growth factor I (IGF-I) as well as GH responses to GH-releasing hormone (GHRH) were studied in 22 subjects (7 females, 15 males), aged between 65 and 86 years. The study was aimed at investigating the possible correlations between the age-dependent GH-IGF-I axis decline and the cognitive function - assessed by the Mini Mental State Examination (MMSE). The relationship between hormonal data, cognition and age, body weight, body mass index (BMI), some nutritional indices (triceps skinfolds, TSF, mid-arm circumference, MAC), and physical activity - quantified by the physical functioning index (PFI)--were also analyzed. GH basal levels were within the normal range, while GH responses to GHRH were blunted in most cases. GH peaks after GHRH were directly correlated with GH basal values. IGF-I serum levels were found to be in the lower part of the reference range for adult subjects or below it. GH responses to GHRH, but not GH and IGF-I basal levels, were inversely correlated with subject age. GH secretion areas after GHRH were inversely correlated with BMI, but no further correlations between GH data and clinical or nutritional parameters were found. MMSE values directly correlated with MAC and PFI values. IGF-I levels were directly correlated with MMSE scores, being lowered in patients with more advanced cognitive deterioration, and with MAC values--the decrease of which is thought to reflect protein caloric malnutrition--but not with body weight, BMI, TSF and PFI. MMSE-related protein caloric malnutrition and decreased physical activity possibly take part in affecting IGF- I function in subjects with mild cognitive impairment and, reciprocally, IGF-I decrement might affect neuronal function.
对22名年龄在65至86岁之间的受试者（7名女性，15名男性）的基础生长激素（GH）、胰岛素样生长因子I（IGF-I）以及GH对生长激素释放激素（GHRH）的反应进行了研究。该研究旨在调查年龄依赖性GH-IGF-I轴下降与通过简易精神状态检查表（MMSE）评估的认知功能之间的可能相关性。还分析了激素数据、认知与年龄、体重、体重指数（BMI）、一些营养指标（肱三头肌皮褶厚度，TSF，上臂中部周长，MAC）以及通过身体功能指数（PFI）量化的身体活动之间的关系。GH基础水平在正常范围内，而在大多数情况下，GH对GHRH的反应减弱。GHRH后的GH峰值与GH基础值直接相关。发现IGF-I血清水平处于成人受试者参考范围的下限或低于该范围。GH对GHRH的反应，而非GH和IGF-I基础水平，与受试者年龄呈负相关。GHRH后的GH分泌面积与BMI呈负相关，但未发现GH数据与临床或营养参数之间的进一步相关性。MMSE值与MAC和PFI值直接相关。IGF-I水平与MMSE评分直接相关，在认知功能衰退更严重的患者中降低，并且与MAC值相关——MAC值的降低被认为反映蛋白质热量营养不良——但与体重、BMI、TSF和PFI无关。MMSE相关的蛋白质热量营养不良和身体活动减少可能参与影响轻度认知障碍受试者的IGF-I功能，反之，IGF-I减少可能影响神经元功能。
