Yamaguchi A, Goi T, Seki K, Ohtaki N, Maehara M, Kobayashi T, Niimoto S, Katayama K, Hirose K, Nakagawara G, Matsukawa S
First Department of Surgery, Fukui Medical University, Japan.
Oncology. 1998 Sep-Oct;55(5):400-3. doi: 10.1159/000011885.
To evaluate their prognostic value, the expressions of CD44v and sialyl LeX (SLX) in colorectal cancers were studied immunohistochemically. Tissue specimens were reacted with monoclonal antibodies (mAb) CD44-1V and CSLEX-1. Of the 145 colorectal cancer patients undergoing curative resection, 59 (40.7%) were positive for mAb CD44-1V, and 40 (27.6%) were positive for mAb CSLEX-1. There was a significant correlation between the combined expression of SLX and CD44v8-10 and lymph node metastasis. The patients with tumors negative for CD44v8-10 and SLX had the most favorable prognoses. Conversely, the patients with tumors positive for both CD44v8-10 and SLX had a high recurrence rate and the poorest prognoses. In a multivariate analysis using the Cox regression model, the combined expression of SLX and CD44v8-10 emerged as an independent prognostic indicator. These results suggested that the combined expression of CD44v8-10 and SLX may be a biologic marker of prognostic significance.
为评估其预后价值，采用免疫组织化学方法研究了结直肠癌中CD44v和唾液酸化Lewis X（SLX）的表达。组织标本与单克隆抗体（mAb）CD44-1V和CSLEX-1反应。在145例行根治性切除的结直肠癌患者中，59例（40.7%）mAb CD44-1V呈阳性，40例（27.6%）mAb CSLEX-1呈阳性。SLX和CD44v8-10的联合表达与淋巴结转移之间存在显著相关性。CD44v8-10和SLX均为阴性的肿瘤患者预后最佳。相反，CD44v8-10和SLX均为阳性的肿瘤患者复发率高且预后最差。在使用Cox回归模型的多因素分析中，SLX和CD44v8-10的联合表达成为独立的预后指标。这些结果表明，CD44v8-10和SLX的联合表达可能是具有预后意义的生物学标志物。
