Rodis J F, Borgida A F, Wilson M, Egan J F, Leo M V, Odibo A O, Campbell W A
Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, USA.
Am J Obstet Gynecol. 1998 Oct;179(4):985-8. doi: 10.1016/s0002-9378(98)70203-0.
Our purpose was to investigate the evaluation and management of parvovirus infection during pregnancy.
Surveys were mailed to members of the Society of Perinatal Obstetricians residing in the United States and Canada in July 1997. They were asked about their evaluation and management of parvovirus infection, including whether they repeated and confirmed serologic studies, what their initial and follow-up evaluations included, whether they had had any cases of parvovirus-associated hydrops in the past 2 years, and if so, what were the management and outcomes of the hydropic fetuses.
Surveys were mailed to 1623 members of the Society of Perinatal Obstetricians and 541 completed surveys were returned. Sixty-eight percent of the respondents repeated and confirmed serologic studies. Eighty-nine percent used ultrasonography in their initial management of pregnant patients with recent parvovirus infection, 7.5% used amniocentesis for polymerase chain reaction, and 2% used fetal blood sampling. The outcomes of the 539 cases of parvovirus-induced hydrops included spontaneous resolution in 34%, death without intrauterine transfusion in 30%, resolution after intrauterine transfusion in 29%, death after intrauterine transfusion in 6%, and pregnancy termination in 1%. Almost all cases of nonimmune hydrops reported occurred between 16 and 32 weeks.
Approximately one third of the cases of parvovirus-induced nonimmune hydrops resolved spontaneously, whereas 83.5% of hydropic fetuses transfused survived.
我们的目的是研究孕期细小病毒感染的评估与管理。
1997年7月向居住在美国和加拿大的围产期产科医师协会成员邮寄了调查问卷。询问他们对细小病毒感染的评估与管理情况，包括是否重复并确认血清学检查、初始及随访评估包括哪些内容、在过去2年中是否有细小病毒相关水肿的病例，若有，水肿胎儿的管理及结局如何。
向围产期产科医师协会的1623名成员邮寄了调查问卷，共收回541份完整问卷。68%的受访者重复并确认了血清学检查。89%的受访者在初次管理近期感染细小病毒的孕妇时使用了超声检查，7.5%使用羊膜腔穿刺术进行聚合酶链反应，2%使用胎儿血样采集。539例细小病毒引起的水肿病例的结局包括34%自然消退、30%未进行宫内输血而死亡、29%在宫内输血后消退、6%在宫内输血后死亡、1%终止妊娠。几乎所有报告的非免疫性水肿病例都发生在孕16至32周之间。
约三分之一的细小病毒引起的非免疫性水肿病例自然消退，而接受输血的水肿胎儿有83.5%存活。
