Mair R G, Burk J A, Porter M C
Department of Psychology, University of New Hampshire, Durham 03824, USA.
Behav Neurosci. 1998 Aug;112(4):772-92. doi: 10.1037//0735-7044.112.4.772.
Lesions of the intralaminar thalamic nuclei (ILn), the medial wall (MW) area of prefrontal cortex, and the hippocampus were compared and found to have distinct effects on delayed matching-to-sample (DMS) and delayed non-matching-to-sample (DNMS) tasks based on different types of stimulus cues. Hippocampal lesions impaired DNMS trained in a radial arm maze but had little effect on DMS trained with retractable levers or olfactory DNMS. MW lesions affected the DMS task but had limited effects on olfactory DNMS and radial arm maze DNMS. ILn lesions resulted in a more generalized pattern of impairment for radial maze tasks and (in previous studies) for the DMS and olfactory DNMS tasks. Only the hippocampal lesion was associated with a delay-dependent impairment. It is argued that ILn lesions disrupt remembering through their effects on the recurrent, feedback pathways that link functionally related areas of the basal ganglia and cortex.
对丘脑板内核（ILn）、前额叶皮质内侧壁（MW）区域和海马体的损伤进行了比较，发现基于不同类型的刺激线索，它们对延迟样本匹配（DMS）和延迟非样本匹配（DNMS）任务有不同的影响。海马体损伤会损害在放射状臂迷宫中训练的DNMS，但对用可伸缩杠杆训练的DMS或嗅觉DNMS影响很小。MW损伤影响DMS任务，但对嗅觉DNMS和放射状臂迷宫DNMS的影响有限。ILn损伤导致放射状迷宫任务以及（在先前研究中）DMS和嗅觉DNMS任务出现更广泛的损伤模式。只有海马体损伤与延迟依赖性损伤有关。有人认为，ILn损伤通过影响连接基底神经节和皮质功能相关区域的循环反馈通路来破坏记忆。
