Girón J M, Muñoz A, Caro P, Rodríguez F, Vila M J
Sección de Neurología, Hospital del Servicio Andaluz de Salud, Jerez de la Frontera.
Neurologia. 1998 Jun-Jul;13(6):307-10.
Patients with subclinical cobalamin deficiency may develop a subacute myeloneuropathy after nitrous oxide anesthesia. Frequently they have hematologic manifestations, however there is only a few reports of spinal lesions shown on MR and particularly of the effects of cobalamin replacement therapy on these lesions. We describe a patient with unsuspected cobalamin deficiency who developed subacute combined degeneration of the spinal cord after nitrous oxide anesthesia. MR showed high intensity in dorsal columns on T2-weighted image, and posterior resolution of abnormalities after therapy. We discuss the importance of preoperative hematologic manifestations for select high risk patients and prevent this complication. On the other hand, we consider MR as a useful tool to improve our knowledge in the pathophysiology of the neurologic manifestations of the process.
亚临床钴胺素缺乏的患者在接受氧化亚氮麻醉后可能会发生亚急性脊髓神经病。他们常常有血液学表现,然而,仅有少数关于磁共振成像(MR)显示脊髓病变的报道,特别是关于钴胺素替代疗法对这些病变影响的报道。我们描述了一名未被怀疑有钴胺素缺乏的患者,其在接受氧化亚氮麻醉后发生了亚急性联合变性。MR显示在T2加权图像上脊髓后索呈高信号,治疗后异常情况得到改善。我们讨论了术前血液学表现对选定高危患者的重要性以及预防这种并发症。另一方面,我们认为MR是一种有用的工具,可增进我们对该疾病神经学表现病理生理学的认识。