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缓冲作用：冗余DNA可能具有的被动稳态作用。

Buffering: a possible passive-homeostasis role for redundant DNA.

作者信息

Vinogradov A E

机构信息

Institute of Cytology, RussianAcademy of Sciences, St Petersburg 194064, Russia

出版信息

J Theor Biol. 1998 Jul 27;193(2):197-9. doi: 10.1006/jtbi.1997.0629.

DOI:10.1006/jtbi.1997.0629
PMID:9735012
Abstract

A new general role for redundant (apparently non-coding) DNA is speculated: buffering the effect of fluctuations in intra-cellular solute composition on chromatin condensation state in its condensed form and on binding of DNA-tropic proteins and other ligands in its decondensed form. The "buffering" DNA performing such passive-homeostasis (energy-independent) function, can provide selective advantage in ecological niches with a low energy supply.

摘要

推测冗余（明显非编码）DNA有一个新的普遍作用：以其浓缩形式缓冲细胞内溶质组成波动对染色质凝聚状态的影响，以其解聚形式缓冲对亲DNA蛋白和其他配体结合的影响。执行这种被动稳态（不依赖能量）功能的“缓冲”DNA，能在低能量供应的生态位中提供选择优势。

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