Lavretskaia E F, Libinzon R E, Mal'dov D G, Ratnikov L A, Chistiakov V V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(8):1228-31.
Experiments on rats of the Wistar strain has shown that preliminary repeated introduction of phenobarbitals and chlordiazepoxide weakens the pharmacological effect of medications, increases the liver weight and the protein content, RNA, R-450 cytochrome, accelerates the oxidation of substrates, but to a higher degree of hexobarbital. Aminazine and mellipramine do not significantly influence these indices changing, however, the affinity of R-450 cytochrome to different substrates and the speed of their oxidation.
对Wistar品系大鼠的实验表明，预先反复给予苯巴比妥和氯氮卓会削弱药物的药理作用，增加肝脏重量以及蛋白质、RNA、R-450细胞色素的含量，加速底物氧化，但对己巴比妥的影响程度更高。氯丙嗪和米帕明对这些指标变化没有显著影响，然而，R-450细胞色素对不同底物的亲和力及其氧化速度会受到影响。
