Aurengo A, Delbot T, Leenhardt L, Franc B, Epstein O, Simonet M L, Moutet A
Service Biophysique 2--Groupe hospitalier Pitié-Salpétrière, Paris.
Bull Acad Natl Med. 1998;182(5):955-76; discussion 976-9.
As a consequence of the Chernobyl nuclear power plant accident, a considerable increase of thyroid cancer among contaminated children has been reported in Ukraine, Belarus and Russia. A group of 29 children aged from 5 months to 10 years (mean 4.7 years) at the time of the accident, with a papillary thyroid cancer, have been examined at the Pitié-Salpêtrière hospital in Paris. The cancer was discovered by systematic ultrasonography in only 25% of cases. No reliable dosimetric estimation was achieved. The initial surgical treatment was performed in Ukraine. Cervical lymph node and pulmonary metastases were present in 24 and 11 cases respectively. A complementary surgical treatment was necessary for 9 children and one to four radioiodine treatments were given to 24 children. With a mean delay of 7 years after the cancer discovery, an apparent cure or a remission was obtained for 20 children, 6 children have cervical lymph node metastases requiring a surgical treatment and 3 have evolving lung metastases. The management of the great number of foreseeable cases of thyroid cancer requires an improved systematic screening, a large number of rooms dedicated to high activity radioiodine treatments, funds for disposable material and training missions.
作为切尔诺贝利核电站事故的后果,据报道在乌克兰、白俄罗斯和俄罗斯,受污染儿童的甲状腺癌显著增加。一组在事故发生时年龄从5个月至10岁(平均4.7岁)、患有甲状腺乳头状癌的29名儿童,在巴黎皮提耶-萨尔佩特里埃医院接受了检查。仅25%的病例是通过系统性超声检查发现癌症的。未实现可靠的剂量测定评估。最初的手术治疗在乌克兰进行。分别有24例和11例出现颈部淋巴结转移和肺转移。9名儿童需要进行补充性手术治疗,24名儿童接受了一至四次放射性碘治疗。在发现癌症后平均7年,20名儿童实现了明显治愈或缓解,6名儿童有需要手术治疗的颈部淋巴结转移,3名儿童有进展性肺转移。应对大量可预见的甲状腺癌病例需要改进系统性筛查、大量用于高活性放射性碘治疗的病房、一次性材料资金以及培训任务。