Chang Y F, Novosel V, Dubovi E, Wong S J, Chu F K, Chang C F, Del Piero F, Shin S, Lein D H
Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Parasitol. 1998 Jul 31;78(2):137-45. doi: 10.1016/s0304-4017(98)00133-2.
Human blood collected from two patients from Westchester County, New York with human granulocytic ehrlichia (HGE) infection was inoculated into two ponies. Inoculated ponies developed clinical signs similar to a previous report (Madigan et al., 1995). Histopathological changes involved follicular hyperplasia of lymphoid tissues. HGE DNA was detected by PCR in muscle, fascia, peritoneum, and adrenal gland after the ponies produced a high level of antibodies to HGE. We suggest that HGE may reside in poorly vascularized connective tissues, where the antibodies may have some difficulties to penetrate, resulting in persistent infection. Since HGE and E. equi cause very similar diseases in both humans and horses, they may be the same organism with minor genetic differences.
从纽约韦斯特切斯特县两名感染人粒细胞埃立克体（HGE）的患者采集的人血被接种到两匹小马体内。接种后的小马出现了与之前报告（Madigan等人，1995年）相似的临床症状。组织病理学变化包括淋巴组织的滤泡增生。在小马产生高水平的抗HGE抗体后，通过聚合酶链反应（PCR）在肌肉、筋膜、腹膜和肾上腺中检测到了HGE DNA。我们认为，HGE可能存在于血管化不良的结缔组织中，抗体可能难以穿透这些组织，从而导致持续感染。由于HGE和马埃立克体在人和马中引起非常相似的疾病，它们可能是具有微小基因差异的同一生物体。
