Goldowitz D, Hamre K
Dept of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA.
Trends Neurosci. 1998 Sep;21(9):375-82. doi: 10.1016/s0166-2236(98)01313-7.
The molecular underpinnings of cerebellar development are being established through the identification of naturally occurring mutated genes and the knockout of other genes. Sets of genes expressed in the regions of the mes- and metencephalon have been shown to play a crucial role in specifying the cerebellar anlage. Other genes have been shown to be crucial to early granule-cell development, migration of Purkinje and granule cells, and neuron-glia interactions. However, the process of development will ultimately be understood in terms of cellular interactions and the roles that each cell type plays in the assembly of cerebellar structure. One of the most important interactions is between granule and Purkinje cells. This relationship has been shown to be crucial for the control of cell number, migration of neuroblasts and cell differentiation.
通过鉴定自然发生的突变基因和敲除其他基因，小脑发育的分子基础正在逐步确立。已表明在中脑和后脑区域表达的几组基因在确定小脑原基中起着关键作用。其他基因已被证明对早期颗粒细胞发育、浦肯野细胞和颗粒细胞的迁移以及神经元与神经胶质细胞的相互作用至关重要。然而，发育过程最终将根据细胞间相互作用以及每种细胞类型在小脑结构组装中所起的作用来理解。最重要的相互作用之一是颗粒细胞与浦肯野细胞之间的相互作用。这种关系已被证明对控制细胞数量、神经母细胞迁移和细胞分化至关重要。
