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就诊时易于获得的临床预测指标可预测不稳定型心绞痛的资源利用情况。

Clinical predictors easily obtained at presentation predict resource utilization in unstable angina.

作者信息

Calvin J E, Klein L W, VandenBerg B J, Meyer P, Ramirez-Morgen L M, Parrillo J E

机构信息

Section of Cardiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill 60612, USA.

出版信息

Am Heart J. 1998 Sep;136(3):373-81. doi: 10.1016/s0002-8703(98)70209-1.

DOI:10.1016/s0002-8703(98)70209-1
PMID:9736126
Abstract

OBJECTIVE

To determine if a risk prediction model for patients with unstable angina would predict resource utilization.

METHODS AND RESULTS

Four hundred sixty-five consecutive patients admitted for unstable angina to a tertiary care university-based medical center were prospectively evaluated from June 1, 1992, to June 30, 1995. The proportion of patients receiving coronary angiography, coronary angioplasty, and coronary artery bypass grafting were analyzed according to four risk groups on the basis of a previously published model: Group 1, <2% risk of major complication; Group 2, 2.1% to 5% risk; Group 3, 5.1 % to 15% risk; and Group 4, >15.1 % risk. Hospital length of stay and estimated cost of hospitalization based on DRG and specific payer ratio of cost-to-charge were also compared between groups. Multiple linear regression analysis was used to determine the influence of estimated risk and procedures on hospital costs. The four groups were well matched for gender, hypertension, tobacco history, and previous percutaneous transluminal coronary angioplasty and myocardial infarction. Group 4 had a higher incidence of previous coronary bypass grafting (35% vs 10%, p=0.001) and triple vessel or left main coronary artery disease compared with Group 1 (44% vs 13%, p=0.041). Group 4 patients were more likely to be admitted to the coronary care unit compared with Group 2 or Group 1 patients (80% vs Group 1: 51% [p= 0.001]; and vs Group 2: 53% [p=0.001]), more likely to receive heparin (87% vs 71%, p=0.007), and more likely to receive a beta-blocker or calcium channel blocker (89% vs 74%, p=0.008) than Group 1. Coronary angioplasty rates were similar for all groups, but Group 4 patients were more likely to receive coronary bypass grafting than Group 2 or Group 1 (27% vs Group 2: 12%, p=0.004 and vs Group 1: 8%, p=0.002). Hospital length of stay was highest in Group 4 and lowest for Group 1. Average hospital costs were significantly less in Group 3 than in Group 4, but higher than in Group 1. Multivariate analysis determined a dependency of costs on risk group with Group 2 having costs 31.4% (95% CI=9.8 to 57.2), Group 3 46.7% (24, 3 to 73.1), and Group 4 75% (46.9 to 110.7) higher than Group 1. The use of procedures also significantly increased costs, with PTCA-treated patients having a 44.9% (26.7 to 65.7) increase in costs compared with medically treated patients, and surgically treated patients having a 204.7% increase in costs.

CONCLUSION

Resource utilization as assessed by the use of revascularization procedures, length of stay, and hospital costs are influenced by patient acuity estimated from a prediction model on the basis of estimated risk of cardiac complications. The model exerts independent influence on cost even after adjustment for various procedures. The use of revascularization procedures, especially coronary artery surgery, remains a large determinant of hospital cost.

摘要

目的

确定不稳定型心绞痛患者的风险预测模型是否能预测资源利用情况。

方法与结果

1992年6月1日至1995年6月30日,对一所大学附属三级医疗中心连续收治的465例不稳定型心绞痛患者进行前瞻性评估。根据先前发表的模型将患者分为四个风险组,分析接受冠状动脉造影、冠状动脉成形术和冠状动脉旁路移植术的患者比例:第1组,主要并发症风险<2%;第2组,风险为2.1%至5%;第3组,风险为5.1%至15%;第4组,风险>15.1%。还比较了各组之间的住院时间以及基于疾病诊断相关分组(DRG)和特定付费者费用与收费比率估算的住院费用。采用多元线性回归分析来确定估算风险和手术对医院费用的影响。四组在性别、高血压、吸烟史以及既往经皮腔内冠状动脉成形术和心肌梗死方面匹配良好。与第1组相比,第4组既往冠状动脉旁路移植术的发生率更高(35%对10%,p = 0.001),三支血管或左主干冠状动脉疾病的发生率也更高(44%对13%,p = 0.041)。与第2组或第1组患者相比,第4组患者更有可能入住冠心病监护病房(80%对第1组:51% [p = 0.001];对第2组:53% [p = 0.001]),更有可能接受肝素治疗(87%对71%,p = 0.007),也更有可能接受β受体阻滞剂或钙通道阻滞剂治疗(89%对74%,p = 0.008)。所有组的冠状动脉成形术发生率相似,但与第2组或第1组相比,第4组患者更有可能接受冠状动脉旁路移植术(27%对第2组:12%,p = 0.004;对第1组:8%,p = 0.002)。第组4的住院时间最长,第1组最短。第3组的平均住院费用显著低于第4组,但高于第1组。多变量分析确定费用依赖于风险组,第2组的费用比第1组高31.4%(95%可信区间=9.8至57.2),第3组高46.7%(24.3至73.1),第4组高75%(46.9至110.7)。手术的使用也显著增加了费用,接受经皮冠状动脉腔内血管成形术(PTCA)治疗的患者与接受药物治疗的患者相比,费用增加了44.9%(26.7至65.7),接受手术治疗的患者费用增加了204.7%。

结论

基于心脏并发症估计风险的预测模型所评估的患者病情严重程度,会影响通过血运重建手术的使用、住院时间和医院费用来评估的资源利用情况。即使在对各种手术进行调整后,该模型对费用仍有独立影响。血运重建手术的使用,尤其是冠状动脉手术,仍然是医院费用的一个主要决定因素。

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