低镁浓度是冠心病的危险因素吗？社区动脉粥样硬化风险（ARIC）研究。

Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study.

作者信息

Liao F, Folsom A R, Brancati F L

机构信息

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.

出版信息

Am Heart J. 1998 Sep;136(3):480-90. doi: 10.1016/s0002-8703(98)70224-8.

DOI:10.1016/s0002-8703(98)70224-8

PMID:9736141

Abstract

BACKGROUND

Hypomagnesemia has been hypothesized to play a role in coronary heart disease (CHD), but few prospective epidemiologic studies have been conducted.

METHODS AND RESULTS

We examined the relation of serum and dietary magnesium with CHD incidence in a sample of middle-aged adults (n=13,922 free of baseline CHD) from 4 US communities. Over 4 to 7 years of follow-up, 223 men and 96 women had CHD develop. After adjustment for sociodemographic characteristics, waist/hip ratio, smoking, alcohol consumption, sports participation, use of diuretics, fibrinogen, total and high-density lipoprotein cholesterol levels, triglyceride levels, and hormone replacement therapy, the relative risk of CHD across quartiles of serum magnesium was 1.00, 0.92, 0.48, and 0.44 (P for trend=0.009) among women and 1.00, 1.32, 0.95, and 0.73 (P for trend=0.07) among men. The adjusted relative risk of CHD for the highest versus the lowest quartile of dietary magnesium was 0.69 in men (95% confidence interval 0.45 to 1.05) and 1.32 in women (0.68 to 2.55).

CONCLUSIONS

These findings suggest that low magnesium concentration may contribute to the pathogenesis of coronary atherosclerosis or acute thrombosis.

摘要

背景

低镁血症被认为在冠心病（CHD）中起一定作用，但前瞻性流行病学研究较少。

方法与结果

我们在来自美国4个社区的中年成年人样本（n = 13922，无基线冠心病）中研究了血清镁和膳食镁与冠心病发病率的关系。在4至7年的随访中，223名男性和96名女性发生了冠心病。在调整了社会人口统计学特征、腰臀比、吸烟、饮酒、体育活动、利尿剂使用、纤维蛋白原、总胆固醇和高密度脂蛋白胆固醇水平、甘油三酯水平以及激素替代治疗后，女性血清镁四分位数组中冠心病的相对风险分别为1.00、0.92、0.48和0.44（趋势P值 = 0.009），男性分别为1.00、1.32、0.95和0.73（趋势P值 = 0.07）。膳食镁最高四分位数与最低四分位数相比，男性冠心病的调整后相对风险为0.69（95%置信区间0.45至1.05），女性为1.32（0.68至2.55）。