Copp Katherine L, Steffen Lyn M, Yi So-Yun, Lutsey Pamela L, Rebholz Casey M, Rooney Mary R
University of Minnesota School of Public Health, Division of Epidemiology and Community Health, 1300 South Second St, Suite 300, Minneapolis, MN 55454, USA.
Johns Hopkins University Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD 21287, USA.
Eur J Prev Cardiol. 2025 Apr 2;32(5):386-393. doi: 10.1093/eurjpc/zwae251.
Numerous studies have shown inverse associations between serum magnesium (Mg) and risk of cardiovascular disease (CVD), but studies of dietary Mg have not been consistent. To examine the association of a Mg-rich diet score with risks of CVD, coronary heart disease (CHD), and ischaemic stroke in the Atherosclerosis Risk in Communities (ARIC) study.
There were 15 022 Black and White adults without prevalent CVD at baseline (1987-89) included in this analysis. Diet was assessed at two visits 6 years apart using an interviewer-administered 66-item food frequency questionnaire. A Mg-rich diet score was created that included servings of whole grain products, nuts, vegetables, fruit, legumes, coffee, and tea. Cox proportional hazard regression evaluated associations of incident CVD, CHD, and stroke across quintiles of Mg-rich diet score, adjusting for demographics, lifestyle factors, and clinical characteristics. Over >30 years of follow-up, there were 3531 incident CVD events (2562 CHD, 1332 ischaemic stroke). Participants who consumed more Mg-rich foods were older, female, White, had lower blood pressure, fewer were not current smokers, and more reported being physically active. A Mg-rich diet was inversely associated with incident CVD (HRQ5 vs. Q1 = 0.87, 95% CI: 0.77-0.98, Ptrend = 0.02) and CHD (HRQ5 vs. Q1 = 0.82, 95% CI: 0.71-0.95, Ptrend = 0.01); however, the diet-stroke association was null (HRQ5 vs. Q1 = 1.00, 95% CI: 0.82-1.22, Ptrend = 0.97).
Consuming a diet including Mg-rich foods, such as whole grains, nuts, vegetables, fruits, legumes, coffee, and tea, is associated with lower risk of CVD and CHD, but not ischaemic stroke.
众多研究表明血清镁（Mg）与心血管疾病（CVD）风险之间存在负相关，但关于膳食镁的研究结果并不一致。在社区动脉粥样硬化风险（ARIC）研究中，探讨富含镁的饮食评分与CVD、冠心病（CHD）和缺血性中风风险之间的关联。
本分析纳入了15022名在基线时（1987 - 1989年）无CVD病史的黑人和白人成年人。使用由访员管理的66项食物频率问卷在相隔6年的两次访视中评估饮食情况。创建了一个富含镁的饮食评分，其中包括全谷物产品、坚果、蔬菜、水果、豆类、咖啡和茶的摄入量。Cox比例风险回归评估了富含镁的饮食评分五分位数与CVD、CHD和中风发病之间的关联，并对人口统计学、生活方式因素和临床特征进行了调整。在超过30年的随访中，发生了3531例CVD事件（2562例CHD，1332例缺血性中风）。食用更多富含镁食物的参与者年龄更大、为女性、是白人、血压更低、当前吸烟者较少，且更多人报告有身体活动。富含镁的饮食与CVD发病呈负相关（HRQ5与Q1 = 0.87，95%CI：0.77 - 0.98，Ptrend = 0.02）和CHD（HRQ5与Q1 = 0.82，95%CI：0.71 - 0.95，Ptrend = 0.01）；然而，饮食与中风的关联不显著（HRQ5与Q1 = 1.00，95%CI：0.82 - 1.22，Ptrend = 0.97）。
食用包含全谷物、坚果、蔬菜、水果、豆类、咖啡和茶等富含镁食物的饮食与较低的CVD和CHD风险相关，但与缺血性中风无关。
