Ketterer B
Department of Oncology, University College Medical School, London, UK.
Free Radic Res. 1998 Jun;28(6):647-58. doi: 10.3109/10715769809065820.
This paper describes the intervention of glutathione-dependent enzymes, in particular the glutathione S-transferases (GSTs), in both the detoxication of electrophilic decomposition products resulting from the attack of oxygen radicals on lipids and DNA; and the prevention of oxygen toxicity generated by redox cycling catecholamine derivatives. The continuing growth of our knowledge of the glutathione S-transferase polygene family is described in terms of the increase in members of known gene families, the discovery of new ones and our increasing knowledge of their activities towards endogenous substrates.
本文描述了谷胱甘肽依赖性酶，特别是谷胱甘肽S-转移酶（GSTs）在以下两方面的作用：一是对氧自由基攻击脂质和DNA所产生的亲电子分解产物进行解毒；二是预防由氧化还原循环儿茶酚胺衍生物产生的氧毒性。文中还阐述了随着已知基因家族成员的增加、新基因家族的发现以及我们对其对内源性底物活性了解的不断深入，我们对谷胱甘肽S-转移酶多基因家族的认识也在持续增长。
