Plasma lipoprotein(a) levels are high in patients with central retinal artery occlusion.

High plasma lipoprotein(a) (Lp[a]) concentration is an independent risk factor for atherosclerosis and thrombosis. To study the implications of Lp(a) in central retinal artery occlusion (CRAO), we examined Lp(a) levels and molecular weights (MWs) of apolipoprotein(a) (apo(a)). Mean Lp(a) concentration was significantly higher in the cases with CRAO than in the controls. Lp(a) levels higher than 30 mg/dl were also more frequent in the CRAO cases than in the controls. Lp(a) concentrations correlated significantly with low-MW isoforms of apo(a). Impaired fibrinolysis and atherogenesis induced by Lp(a) may play a role in the pathophysiology of CRAO. Since high Lp(a) levels were reported in CRVO by other investigators, patients with central retinal vein occlusion (CRVO) were also examined for Lp(a). Although Lp(a) levels were higher in the CRVO cases than in the controls, the difference was not significant. Therefore, high Lp(a) levels may not be associated with venous thrombosis and/or embolism.