脂质体两性霉素B在白细胞减少小鼠体内循环时间延长，治疗严重念珠菌病疗效更佳。
Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice.
作者信息
van Etten E W, Snijders S V, van Vianen W, Bakker-Woudenberg I A
机构信息
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2431-3. doi: 10.1128/AAC.42.9.2431.
Abstract
In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg . day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.
摘要
在患有严重全身性念珠菌病的白细胞减少小鼠中，单剂量治疗（5毫克两性霉素B[AMB]/千克体重）使用长循环聚乙二醇包被的AMB脂质体（PEG-AMB-LIP）可导致死亡率为零，并且肾脏中白色念珠菌的活菌数量显著减少，而每天使用五剂安必素（5毫克AMB/千克·天）治疗的小鼠死亡率为70%。当五剂安必素中的第一剂与一剂低剂量的两性霉素B（0.1毫克AMB/千克）联合使用时，疗效与PEG-AMB-LIP相当。
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