脂质体两性霉素B在血液中循环时间延长后的活性与安必素和两性霉素B去氧胆酸盐对小鼠腹腔巨噬细胞内白色念珠菌的活性比较
Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.
作者信息
van Etten E W, van Vianen W, Hak J, Bakker-Woudenberg I A
机构信息
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2437-9. doi: 10.1128/AAC.42.9.2437.
Abstract
Activity against intracellular Candida albicans was assessed in C. albicans-infected murine peritoneal macrophages exposed to long-circulating pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fungizone. The level of antifungal activity of Fungizone is much higher than that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome show equivalent activity levels. Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity.
摘要
在暴露于长循环聚乙二醇化两性霉素B脂质体（PEG-AMB-LIP）、安必素或两性霉素B的白色念珠菌感染的小鼠腹腔巨噬细胞中评估对细胞内白色念珠菌的活性。两性霉素B的抗真菌活性水平远高于安必素或PEG-AMB-LIP，而PEG-AMB-LIP和安必素显示出相当的活性水平。未感染的巨噬细胞预先暴露于PEG-AMB-LIP或安必素对细胞内抗真菌活性有利。
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