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脂质体两性霉素B在血液中循环时间延长后的活性与安必素和两性霉素B去氧胆酸盐对小鼠腹腔巨噬细胞内白色念珠菌的活性比较

Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.

作者信息

van Etten E W, van Vianen W, Hak J, Bakker-Woudenberg I A

机构信息

Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands.

出版信息

Antimicrob Agents Chemother. 1998 Sep;42(9):2437-9. doi: 10.1128/AAC.42.9.2437.

DOI:10.1128/AAC.42.9.2437
PMID:9736579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105849/
Abstract

Activity against intracellular Candida albicans was assessed in C. albicans-infected murine peritoneal macrophages exposed to long-circulating pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fungizone. The level of antifungal activity of Fungizone is much higher than that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome show equivalent activity levels. Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity.

摘要

在暴露于长循环聚乙二醇化两性霉素B脂质体（PEG-AMB-LIP）、安必素或两性霉素B的白色念珠菌感染的小鼠腹腔巨噬细胞中评估对细胞内白色念珠菌的活性。两性霉素B的抗真菌活性水平远高于安必素或PEG-AMB-LIP，而PEG-AMB-LIP和安必素显示出相当的活性水平。未感染的巨噬细胞预先暴露于PEG-AMB-LIP或安必素对细胞内抗真菌活性有利。

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Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.脂质体两性霉素B在血液中循环时间延长后的活性与安必素和两性霉素B去氧胆酸盐对小鼠腹腔巨噬细胞内白色念珠菌的活性比较
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Int J Nanomedicine. 2015 Mar 5;10:1769-90. doi: 10.2147/IJN.S63155. eCollection 2015.
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本文引用的文献

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Comparative internalization and recycling of different amphotericin B formulations by a macrophage-like cell line.巨噬细胞样细胞系对不同两性霉素B制剂的内化和再循环比较
J Antimicrob Chemother. 1996 Mar;37(3):519-33. doi: 10.1093/jac/37.3.519.
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Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines.空间稳定作用对体外巨噬细胞摄取以及由烷基磷酰胆碱制成的脂质体固定水层厚度的影响。
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Interactions of liposomal amphotericin B with extracellular and intracellular Candida albicans.脂质体两性霉素B与细胞外和细胞内白色念珠菌的相互作用。
J Antimicrob Chemother. 1995 Dec;36(6):961-74. doi: 10.1093/jac/36.6.961.
5
Binding and uptake of liposomes containing a poly(ethylene glycol) derivative of cholesterol (stealth liposomes) by the macrophage cell line J774: influence of PEG content and its molecular weight.巨噬细胞系J774对含有胆固醇聚乙二醇衍生物的脂质体（隐形脂质体）的结合与摄取：聚乙二醇含量及其分子量的影响
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Amphotericin B liposomes with prolonged circulation in blood: in vitro antifungal activity, toxicity, and efficacy in systemic candidiasis in leukopenic mice.血液中循环时间延长的两性霉素B脂质体：体外抗真菌活性、毒性及对白细胞减少小鼠系统性念珠菌病的疗效
Antimicrob Agents Chemother. 1995 Sep;39(9):1954-8. doi: 10.1128/AAC.39.9.1954.
7
Liposomes with prolonged blood circulation and selective localization in Klebsiella pneumoniae-infected lung tissue.具有延长血液循环时间并能在肺炎克雷伯菌感染的肺组织中选择性定位的脂质体。
J Infect Dis. 1993 Jul;168(1):164-71. doi: 10.1093/infdis/168.1.164.
8
Efficacies of amphotericin B-desoxycholate (Fungizone), liposomal amphotericin B (AmBisome) and fluconazole in the treatment of systemic candidosis in immunocompetent and leucopenic mice.两性霉素B去氧胆酸盐（两性霉素B，商品名：Fungizone）、脂质体两性霉素B（商品名：安必素）和氟康唑在免疫功能正常和白细胞减少小鼠中治疗系统性念珠菌病的疗效。
J Antimicrob Chemother. 1993 Nov;32(5):723-39. doi: 10.1093/jac/32.5.723.
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Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiella pneumoniae-infected lung tissue.庆大霉素或头孢他啶包裹于脂质体中，具有延长血液循环时间并增强在肺炎克雷伯菌感染肺组织中的定位效果。
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Sterically stabilized liposomes: physical and biological properties.空间稳定脂质体：物理和生物学特性。
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