KatG基因中的Ser315Thr替换在源自俄罗斯圣彼得堡地区的基因异质性耐多药结核分枝杆菌分离株中占主导地位。
A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia.
作者信息
Marttila H J, Soini H, Eerola E, Vyshnevskaya E, Vyshnevskiy B I, Otten T F, Vasilyef A V, Viljanen M K
机构信息
Mycobacterial Reference Laboratory, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2443-5. doi: 10.1128/AAC.42.9.2443.
Abstract
Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS6110 fingerprints.
摘要
对来自27株俄罗斯结核分枝杆菌分离株的katG和rpoB部分进行测序，以分别检测导致对异烟肼（INH）和利福平（RMP）耐药的突变。所有24株对INH耐药的分离株均有katG突变，其中22株（91.7%）携带编码Ser315Thr移位的突变。在21株对RMP耐药的分离株中均检测到rpoB突变，其中Ser531Leu是最常见的编码变化。只有两株分离株具有相同的IS6110指纹图谱。
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