Ripka A S, Rich D H
Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison 53706, USA.
Curr Opin Chem Biol. 1998 Aug;2(4):441-52. doi: 10.1016/s1367-5931(98)80119-1.
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.
已取得重大发现，找到了新型I型和III型肽模拟物抑制剂，用于肽衍生系统。发现了半胱氨酸蛋白酶和肾素的新型可逆抑制剂，以及白细胞介素-1β转化酶、中性内肽酶、单纯疱疹病毒蛋白酶、凝血酶、HIV蛋白酶、Ras法尼基转移酶、RGD基序、凝血因子Xa和各种天冬氨酸蛋白酶的肽模拟物抑制剂的更多实例。
