Bradley R
Central Veterinary Laboratory, New Haw, Addlestone, UK.
Dev Biol Stand. 1998;93:65-72.
The BSE epidemic in the UK is declining rapidly in response to control measures and is en route for eradication by the year 2001. BSE infectivity is restricted in clinically affected natural cases of BSE to central nervous tissues. BSE agent has been isolated from the intestine of experimentally orally-infected cattle from six to 18 months post-challenge. A small maternal risk factor for BSE has been identified but this will not stop the eradication of BSE. To protect the integrity of biological products from the risks associated with the unknown hazard of BSE for man it is recommended that only safe sources of animals and tissues are used. Inactivation procedures employed during processing will provide further guarantees.
英国的疯牛病疫情在控制措施的作用下正迅速下降，并有望在2001年根除。在临床受影响的疯牛病自然病例中，疯牛病的传染性仅限于中枢神经组织。在实验性经口感染的牛受到攻击后6至18个月，已从其肠道中分离出疯牛病病原体。已确定了一个较小的疯牛病母源风险因素，但这不会阻碍疯牛病的根除。为保护生物制品的完整性，使其免受与疯牛病对人类未知危害相关的风险，建议只使用安全的动物和组织来源。加工过程中采用的灭活程序将提供进一步保障。
