Sandblom P, Mirkovitch V, Gardiol D
Ann Surg. 1976 Jun;183(6):679-84. doi: 10.1097/00000658-197606000-00010.
Cases of traumatic hemobilia are often characterized by a protracted history with recurrent episodes of hemorrhage over many years. It seems that while the liver regenerates quickly and profusely it heals slowly and poorly. This is in contradistinction to the kidneys where lesions often heal within a short time. In order to investigate the cause of this peculiar behavior a series of experiments was performed where local lesions were produced in the musculature, in the kidneys and in the liver of dogs. The healing process was studied at different intervals. There was essentially no difference between the rate and character of healing in the three localities. As the lesions that produce hemobilia are open to the biliary tract, another series of experiments was performed where the healing took place in presence of bile. The effect of this was striking with a very diminished production of fibrinous exudate, granulating tissue and fibrous scar.
创伤性胆道出血病例的特点往往是病史迁延，多年来反复出现出血发作。肝脏似乎虽然再生迅速且大量，但愈合缓慢且不佳。这与肾脏形成对比，肾脏的损伤通常在短时间内就能愈合。为了研究这种特殊现象的原因，进行了一系列实验，在狗的肌肉组织、肾脏和肝脏中制造局部损伤。在不同时间段研究愈合过程。这三个部位在愈合速度和特征上基本没有差异。由于导致胆道出血的损伤通向胆道，又进行了另一系列实验，即在有胆汁存在的情况下进行愈合过程的研究。其效果显著，纤维蛋白渗出物、肉芽组织和纤维瘢痕的生成大幅减少。
