Ljungberg S
Pharmacia and Upjohn AB, Stockholm, Sweden.
Clin Ther. 1998 Jul-Aug;20(4):737-43. doi: 10.1016/s0149-2918(98)80136-7.
In this open-label, parallel-group study, 23 male spinal cord injury patients aged 23 to 73 years (median 54 years) with a total of 30 exudative decubital ulcers were randomly allocated to receive treatment with dextranomer paste (15 ulcers) or conventional saline dressings (15 ulcers). Treatment was applied at least once every 12 hours and continued for a maximum of 15 days, until the ulcer was clean and covered with new granulation tissue and was suitable for skin grafting. The same physician assessed ulcer status (extent of drainage, granulation, erythema, and edema and the presence or absence of necrosis and epithelialization) each time the study nurse changed the dressings. Treatment with dextranomer paste resulted in significantly greater improvement in ulcer drainage compared with saline; 73% versus 13% of the ulcers, respectively, showed > or =25% improvement in drainage from baseline to the end of the study. Both treatments were well tolerated, with no evidence of any local irritation. Dextranomer paste was more effective than saline dressings in the management of decubital ulcers in spinal cord injury patients.
在这项开放标签的平行组研究中，23名年龄在23至73岁（中位年龄54岁）的男性脊髓损伤患者，共有30处渗出性压疮溃疡，被随机分配接受右旋糖酐omer糊剂治疗（15处溃疡）或传统生理盐水敷料治疗（15处溃疡）。治疗至少每12小时进行一次，最长持续15天，直到溃疡清洁并覆盖新的肉芽组织且适合植皮。每次研究护士更换敷料时，由同一位医生评估溃疡状况（引流程度、肉芽、红斑、水肿以及坏死和上皮形成情况）。与生理盐水相比，右旋糖酐omer糊剂治疗使溃疡引流改善更为显著；分别有73%和13%的溃疡从基线到研究结束时引流改善≥25%。两种治疗耐受性良好，没有任何局部刺激的迹象。右旋糖酐omer糊剂在脊髓损伤患者压疮溃疡的管理中比生理盐水敷料更有效。
