通过对NS5-B区域进行系统发育分析证实丙型肝炎病毒的医院内传播。
Confirmation of nosocomial transmission of hepatitis C virus by phylogenetic analysis of the NS5-B region.
作者信息
Norder H, Bergström A, Uhnoo I, Aldén J, Weiss L, Czajkowski J, Magnius L
机构信息
Swedish Institute for Infectious Disease Control, Stockholm, Central Hospital, Karlstad, Sweden.
出版信息
J Clin Microbiol. 1998 Oct;36(10):3066-9. doi: 10.1128/JCM.36.10.3066-3069.1998.
Abstract
Four hepatitis C virus transmission chains at three dialysis units were disclosed by limited sequencing; three of these were disclosed by analysis of the NS5-B region of the genome. Dialysis on the same shift as that during which infected patients were dialyzed was the common factor for seven patients in two chains. Two nurses exposed to needle sticks and their sources of infection constituted two other chains. The strains of three chains belonged to subtype 1a and formed clusters with an intrachain variability of 0 to 6 nucleotides compared to 8 to 37 nucleotides for unrelated strains within this subtype. The clusters were supported by bootstrap values ranging from 89 to 100%.
摘要
通过有限测序发现了三个透析单元中的四条丙型肝炎病毒传播链；其中三条是通过对基因组NS5-B区域的分析发现的。与感染患者透析时段相同班次的透析是两条传播链中七名患者的共同因素。两名暴露于针刺的护士及其感染源构成了另外两条传播链。三条传播链的毒株属于1a亚型，形成了簇，链内变异为0至6个核苷酸，而该亚型内不相关毒株的变异为8至37个核苷酸。这些簇得到了89%至100%的自展值支持。
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