Howard D J, Haribhakti V V
Professorial Unit, Royal National Throat, Nose and Ear Hospital, London.
J Laryngol Otol. 1994 Mar;108(3):230-2. doi: 10.1017/s0022215100126362.
Primary tracheal tumours are extremely rare and present with widely variant clinical and histological features. Treatment methods vary considerably, and few studies have sought to provide adequate guidelines. A retrospective analysis was carried out of all patients treated in our unit between 1965 and 1990. Our experience deals almost exclusively with high tracheal tumours involving the adjacent subglottic region. Squamous carcinoma (SCC) and adenoid cystic carcinoma (ACC) were the commonest subtypes, and presented with dyspnoea and hoarseness as the most frequent symptoms. ACCs occurred commonly in young individuals, presented insidiously, and ran a long, and often, unpredictable course. Endoscopic evaluation revealed the majority of the lesions to be bulky and obstructive in nature. Primary surgery with adjuvant radical radiotherapy, when indicated, appeared to provide optimal results. Debulking surgery followed by radiotherapy provided effective and lasting control in two cases of ACC. Other malignant subtypes behaved aggressively and progressed uncontrolled.
原发性气管肿瘤极为罕见，临床表现和组织学特征差异很大。治疗方法差异很大，很少有研究试图提供充分的指导方针。对1965年至1990年间在我们科室接受治疗的所有患者进行了回顾性分析。我们的经验几乎完全涉及累及相邻声门下区域的高位气管肿瘤。鳞状细胞癌（SCC）和腺样囊性癌（ACC）是最常见的亚型，最常见的症状是呼吸困难和声音嘶哑。ACC常见于年轻人，起病隐匿，病程长且往往不可预测。内镜评估显示大多数病变体积大且具有阻塞性。必要时，原发性手术联合辅助根治性放疗似乎能提供最佳效果。对于两例ACC患者，减瘤手术后放疗提供了有效且持久的控制。其他恶性亚型表现侵袭性强，进展无法控制。
