Ryan K, Butler K, Bellefroid E, Gurdon J B
Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK.
Mech Dev. 1998 Jul;75(1-2):155-8. doi: 10.1016/s0925-4773(98)00084-7.
Our initial description of the Xenopus gene Eomesodermin (Eomes) indicated that it is expressed largely if not entirely in mesodermal cells of gastrula stage embryos. A more detailed examination, described here, shows that it continues to be expressed in the most anterior (future head) mesoderm during gastrula and neurula stages. However, during tail-bud stages, Eomes expression is re-born in the most anterior part of the brain, becoming strongly transcribed in the olfactory region of the telencephalon. This later Eomes expression marks a very localized region of the forebrain distinct from that of Otx-2, anterior to that of En-1 and overlapping that of Sox-3.
