肾功能、蛋白结合以及对二氮嗪的药理反应。
Renal function, protein binding and pharmacological response to diazoxide.
作者信息
Pearson R M, Breckenridge A M
出版信息
Br J Clin Pharmacol. 1976 Feb;3(1):169-75. doi: 10.1111/j.1365-2125.1976.tb00585.x.
Abstract
1 The effect of rapid (10s) injections of diazoxide was studied in ten hypertensive patients with varying degrees of impairment of renal function. 2 There was a significant correlation between the patient's plasma urea concentration and reduction in mean arterial blood pressure. Diazoxide was also shown to be less highly protein bound in patients with renal failure. 3 It is suggested that the explanation for the increased hypotensive effect of diazoxide observed in patients with reduced renal function is related to higher unbound drug concentrations.
摘要
- 对10例肾功能有不同程度损害的高血压患者研究了快速（10秒）注射二氮嗪的效果。2. 患者血浆尿素浓度与平均动脉血压降低之间存在显著相关性。还显示二氮嗪在肾衰竭患者中与蛋白质的结合率较低。3. 有人提出，在肾功能减退患者中观察到二氮嗪降压作用增强的原因与游离药物浓度较高有关。
相似文献
1
Renal function, protein binding and pharmacological response to diazoxide.肾功能、蛋白结合以及对二氮嗪的药理反应。
Br J Clin Pharmacol. 1976 Feb;3(1):169-75. doi: 10.1111/j.1365-2125.1976.tb00585.x.
2
Pharmacokinetics and response to diazoxide in renal failure.肾衰竭患者中氯甲苯噻嗪的药代动力学及反应
Clin Pharmacokinet. 1977 May-Jun;2(3):198-204. doi: 10.2165/00003088-197702030-00004.
3
Decreased plasma protein binding of diazoxide in uremia.
Clin Pharmacol Ther. 1975 Jul;18(1):53-8. doi: 10.1002/cpt197518153.
4
Use of diazoxide in hypertension with renal failure.二氮嗪在伴有肾衰竭的高血压中的应用。
Br Med J. 1971 Oct 16;4(5780):142-5. doi: 10.1136/bmj.4.5780.142.
5
[Acute effect of diazoxide in patients with malignant arterial hypertension and renal insufficicney].
Rev Esp Cardiol. 1972 Mar-Apr;25(2):147-54.
6
Antihypertensive effect of diazoxide given intravenously in small repeated doses.小剂量重复静脉注射二氮嗪的降压作用。
Eur J Clin Pharmacol. 1983;24(2):151-6. doi: 10.1007/BF00613809.
7
[Diazoxide in arterial hypertensive emergencies].
Clin Ter. 1979 May 15;89(3):267-81.
8
Individual titration of diazoxide dosage in the treatment of severe hypertension.在重度高血压治疗中对二氮嗪剂量进行个体化滴定。
Am J Cardiol. 1979 Mar;43(3):627-30. doi: 10.1016/0002-9149(79)90023-7.
9
[The acute crisis of blood pressure and its treatment in childhood (authors transl)].[儿童期血压急性危机及其治疗（作者译）]
Klin Padiatr. 1975 Mar;187(2):171-5.
10
Nonemergency use of slow infusions of diazoxide.二氮嗪缓慢输注的非紧急使用。
Clin Pharmacol Ther. 1975 Aug;18(2):154-7. doi: 10.1002/cpt1975182154.
引用本文的文献
1
The pharmacological role of the kidney.肾脏的药理学作用。
Drugs. 1980 Jan;19(1):31-48. doi: 10.2165/00003495-198019010-00003.
2
Alteration of drug-protein binding in renal disease.肾脏疾病中药物与蛋白质结合的改变。
Clin Pharmacokinet. 1984 Jan;9 Suppl 1:18-26. doi: 10.2165/00003088-198400091-00003.
3
Pharmacokinetic effects of altered plasma protein binding of drugs in renal disease.肾病中药物血浆蛋白结合改变的药代动力学效应。
Eur J Drug Metab Pharmacokinet. 1984 Jul-Sep;9(3):275-82. doi: 10.1007/BF03189651.
4
Disease-induced variations in plasma protein levels. Implications for drug dosage regimens (Part II).疾病引起的血浆蛋白水平变化。对药物给药方案的影响（第二部分）。
Clin Pharmacokinet. 1990 Sep;19(3):218-29. doi: 10.2165/00003088-199019030-00005.
5
Hypertensive encephalopathy.高血压脑病
Br Med J. 1979 Dec 1;2(6202):1387-8.
6
Interrelationship between renal haemodynamics, drug kinetics and drug action.肾脏血流动力学、药物动力学与药物作用之间的相互关系。
Clin Pharmacokinet. 1978 Jan-Feb;3(1):58-71. doi: 10.2165/00003088-197803010-00004.
7
Pharmacokinetics and response to diazoxide in renal failure.肾衰竭患者中氯甲苯噻嗪的药代动力学及反应
Clin Pharmacokinet. 1977 May-Jun;2(3):198-204. doi: 10.2165/00003088-197702030-00004.
8
Drug kinetics and artificial kidneys.药物动力学与人工肾
Clin Pharmacokinet. 1977 Nov-Dec;2(6):403-26. doi: 10.2165/00003088-197702060-00002.
本文引用的文献
1
AUTOMATED DETERMINATION OF SERUM TOTAL CHOLESTEROL.血清总胆固醇的自动测定
Clin Chim Acta. 1964 Oct;10:381-4. doi: 10.1016/0009-8981(64)90073-7.
2
[ON PHARMACOKINETICS OF SULFONAMIDES UNDER PATHOLOGICAL CONDITIONS].[论病理状态下磺胺类药物的药代动力学]
Klin Wochenschr. 1964 Jan 15;42:103-8. doi: 10.1007/BF01478662.
3
CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION.二氮嗪的临床评估：急性高血压的一种新疗法
Circulation. 1963 Aug;28:203-8. doi: 10.1161/01.cir.28.2.203.
4
The ultrafiltrable calcium of human serum. I. Ultrafiltration methods and normal values.人血清中的可超滤钙。I. 超滤方法及正常值。
J Clin Invest. 1957 May;36(5):738-48. doi: 10.1172/JCI103477.
5
Diazoxide blood levels in man.
J Pharm Sci. 1967 Jul;56(7):912-4. doi: 10.1002/jps.2600560730.
6
Hypertensive crisis.高血压危象
JAMA. 1969 Apr 14;208(2):338-42.
7
The fluorometric assay of triglyceride by a semiautomated method.甘油三酯的半自动化荧光测定法。
Anal Biochem. 1968 Oct 24;25(1):246-51. doi: 10.1016/0003-2697(68)90097-3.
8
The effect of disease, drugs, and dilution on the binding of sulfonamides in human plasma.疾病、药物及稀释对磺胺类药物在人血浆中结合的影响。
Clin Pharmacol Ther. 1968 Sep-Oct;9(5):561-7. doi: 10.1002/cpt196895561.
9
The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids.多种药物和脂肪酸对人白蛋白中保泰松 -14C 和华法林 -14C 的置换作用。
Biochem Pharmacol. 1968 Jan;17(1):143-51. doi: 10.1016/0006-2952(68)90166-4.
10
The importance of the rapid administration of diazoxide in accelerated hypertension.
N Engl J Med. 1971 Sep 9;285(11):603-6. doi: 10.1056/NEJM197109092851104.
Zotero 插件