吸烟对喷他佐辛消除个体间差异的影响。
The influence of smoking on the intersubject variation in pentazocine elimination.
作者信息
Vaughan D P, Beckett A H, Robbie D S
出版信息
Br J Clin Pharmacol. 1976 Apr;3(2):279-83. doi: 10.1111/j.1365-2125.1976.tb00604.x.
Abstract
The cumulative urinary excretion over 24 h of pentazocine, under conditions of acidic urinary pH, has been measured in smokers and non-smokers using both male and female subjects (seventy subjects in total). A restricted urban population was studied. An overall three-fold inter-subject variation in elimination was observed. The cumulative urinary excretion of pentazocine was normally distributed in both smokers and non-smokers. Smokers metabolize 40% more pentazocine than non-smokers. It is concluded that induction is principally responsible for the observed subject variability.
摘要
在酸性尿pH条件下，对吸烟者和非吸烟者（共70名受试者，包括男性和女性）测定了喷他佐辛24小时的累积尿排泄量。研究对象为有限的城市人口。观察到消除过程中受试者间总体存在3倍的差异。喷他佐辛的累积尿排泄量在吸烟者和非吸烟者中均呈正态分布。吸烟者代谢的喷他佐辛比非吸烟者多40%。得出的结论是，诱导作用是观察到的受试者差异的主要原因。
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本文引用的文献
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