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Effects of aspirin and prostaglandin E2 on secondary phase aggregation responses of schizophrenic patients treated with chlorpromazine.阿司匹林和前列腺素E2对接受氯丙嗪治疗的精神分裂症患者继发相聚集反应的影响。
Br J Clin Pharmacol. 1976 Oct;3(5):929-33. doi: 10.1111/j.1365-2125.1976.tb00649.x.
2
Platelet aggregation response in schizophrenia and prostaglandin E1.
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Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
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The reliability of 5-hydroxytryptamine induced platelet aggregation responses in schizophrenic patients treated with neuroleptic drugs.使用抗精神病药物治疗的精神分裂症患者中5-羟色胺诱导的血小板聚集反应的可靠性。
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Increased platelet aggregation in patients receiving chlorpromazine: responses to 5-hydroxytryptamine, dopamine and N-dimethyl dopamine.氯丙嗪治疗患者的血小板聚集增加：对 5-羟色胺、多巴胺和 N-二甲基多巴胺的反应。
Br J Clin Pharmacol. 1976 Aug;3(4):649-53. doi: 10.1111/j.1365-2125.1976.tb04889.x.
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The effects of neuroleptic drugs on 5-hydroxytryptamine induced platelet aggregation in schizophrenic patients.抗精神病药物对精神分裂症患者5-羟色胺诱导的血小板聚集的影响。
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Circulation. 1980 Dec;62(6 Pt 2):V19-25.
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Responses of isolated canine basilar artery and human platelet to chlorpromazine and amitriptyline.氯丙嗪和阿米替林对离体犬基底动脉及人血小板的反应。
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Human platelet function as a model for investigating the clinical efficacy of chlorpromazine.人体血小板功能作为研究氯丙嗪临床疗效的模型。
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本文引用的文献

1
A comparison of an effect of different anti-inflammatory drugs on human platelets.不同抗炎药物对人体血小板作用的比较。
J Clin Pathol. 1970 Sep;23(6):522-5. doi: 10.1136/jcp.23.6.522.
2
Effect of prostaglandin E 2 and aspirin on the secondary aggregation of human platelets.前列腺素E2和阿司匹林对人血小板二次聚集的影响。
Nat New Biol. 1972 Mar 15;236(63):45-6. doi: 10.1038/newbio236045a0.
3
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.
4
Platelet physiology and abnormalities of platelet function (first of two parts).血小板生理学与血小板功能异常（两部分中的第一部分）
N Engl J Med. 1975 Sep 11;293(11):531-41. doi: 10.1056/NEJM197509112931105.

阿司匹林和前列腺素E2对接受氯丙嗪治疗的精神分裂症患者继发相聚集反应的影响。

Effects of aspirin and prostaglandin E2 on secondary phase aggregation responses of schizophrenic patients treated with chlorpromazine.

作者信息

Boullin D J, Orr M W

出版信息

Br J Clin Pharmacol. 1976 Oct;3(5):929-33. doi: 10.1111/j.1365-2125.1976.tb00649.x.

DOI:10.1111/j.1365-2125.1976.tb00649.x
PMID:973989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1428953/
Abstract

We investigated the effects of oral aspirin 900 mg upon the platelet aggregation responses to 5-hydroxytryptamine, dopamine or N-dimethyl dopamine in schizophrenic patients chronically treated with chlorpromazine. Most subjects showed enchanced aggregation responses (that is appearance of secondary phase aggregation) to these agents prior to aspirin administration. When aggregation was re-tested 23.5 h after aspirin the secondary phase of the enhanced aggregation responses was abolished. Addition of 0.14-0.3 mumol/l prostaglandin E2 15 s after inducing aggregation partially restored the secondary phase. The observed secondary phase of aggregation may be due to increased prostaglandin synthesis or release.

摘要

我们研究了口服900毫克阿司匹林对长期接受氯丙嗪治疗的精神分裂症患者血小板对5-羟色胺、多巴胺或N-二甲基多巴胺聚集反应的影响。大多数受试者在服用阿司匹林之前对这些药物表现出增强的聚集反应（即出现第二相聚集）。在服用阿司匹林23.5小时后重新测试聚集情况时，增强的聚集反应的第二相消失了。在诱导聚集15秒后添加0.14 - 0.3微摩尔/升前列腺素E2可部分恢复第二相。观察到的聚集第二相可能是由于前列腺素合成或释放增加所致。