O'Brien J R, Finch W, Clark E
J Clin Pathol. 1970 Sep;23(6):522-5. doi: 10.1136/jcp.23.6.522.
Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0.035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.
四名志愿者服用了不同剂量的阿司匹林、吲哚美辛、对乙酰氨基酚、贝诺酯和水杨酸钠。研究了改变血小板功能测试的最小剂量以及在不同剂量水平下这种改变的持续时间。小剂量的吲哚美辛（0.035毫克/千克）有效，但即使是大剂量单次服用，其效果也不能持续。阿司匹林治疗剂量的十分之一（1毫克/千克）有效，更高剂量可使血小板功能改变数天。高治疗剂量的贝诺酯产生了类似阿司匹林的效果。对乙酰氨基酚和水杨酸钠相对无活性。阿司匹林效果的持续可能与乙酰基有关。结合抗炎药作用的一般理论对这些发现进行了综述。
