Bloedel J R, Bracha V
Division of Neurobiology at the Barrow Neurological Institute in Phoenix, AZ, USA.
Anat Rec. 1998 Aug;253(4):118-26. doi: 10.1002/(SICI)1097-0185(199808)253:4<118::AID-AR7>3.0.CO;2-P.
This review examines several of the current postulates regarding the function of one of the most intriguing afferent systems in the brain, the climbing fiber system. The fact that these afferents are activated under a variety of conditions has contributed substantially to the diversity of postulates that have been proposed. In part because of the unique anatomical relationship between individual climbing fibers and the dendritic tree of Purkinje cells, these afferents have been proposed as a key input in establishing long-term plastic changes in the cerebellar cortex. This concept is contrasted with other postulates proposing that the heterosynaptic action of this system produces a short-lasting enhancement rather than a long-term depression of Purkinje cell responsiveness. Although a generally accepted view regarding climbing fiber function does not exist, this review emphasizes the extensive functional insights that have been reported and supports the notion that progress toward a complete understanding of these afferents will require an integration of their morphological characteristics with the fundamental physiological properties of their responses assessed in a variety of contexts and conditions.
本综述探讨了关于大脑中最引人入胜的传入系统之一——攀缘纤维系统功能的几种当前假设。这些传入纤维在多种条件下被激活，这一事实极大地促成了已提出的各种假设。部分由于单个攀缘纤维与浦肯野细胞树突之间独特的解剖关系，这些传入纤维被认为是在小脑皮质建立长期可塑性变化的关键输入。这一概念与其他假设形成对比，其他假设提出该系统的异突触作用产生的是短暂增强而非浦肯野细胞反应性的长期抑制。尽管目前对于攀缘纤维功能尚无普遍接受的观点，但本综述强调了已报道的广泛功能见解，并支持这样一种观点，即要全面理解这些传入纤维，需要将它们的形态特征与在各种背景和条件下评估的反应基本生理特性相结合。
