Schweighofer N
ERATO, Kawato Dynamic Brain Project, Japan Science and Technology Corporation, Kyoto, Japan.
Biol Cybern. 1998 Aug;79(2):97-107. doi: 10.1007/s004220050462.
According to modern views of the cerebellum in motor control, each cerebellar functional unit, or microzone, learns how to execute predictive and coordinative control, based on long-term depression of the granule cell-Purkinje cell synapses. In the present paper, in light of recent experimental and theoretical studies on synaptic elimination and cerebellar motor learning, a model of the formation of cerebellar microzones by climbing fiber synaptic elimination is proposed. It is shown that competition for an activity-dependent supply of neurotrophic factor can reproduce the spatio-temporal characteristics of climbing fiber synaptic elimination. It is further shown that when this elimination is accurate, motor coordination can be acquired in an arm reaching task. In view of the results of the present study, several predictions are proposed.
根据现代关于小脑在运动控制方面的观点，每个小脑功能单元，即微区，基于颗粒细胞 - 浦肯野细胞突触的长时程抑制，学习如何执行预测性和协调性控制。在本文中，鉴于近期关于突触消除和小脑运动学习的实验及理论研究，提出了一种通过攀缘纤维突触消除形成小脑微区的模型。结果表明，对神经营养因子活性依赖性供应的竞争能够重现攀缘纤维突触消除的时空特征。进一步表明，当这种消除精确时，在手臂伸展任务中可以获得运动协调性。鉴于本研究结果，提出了一些预测。
