Sheldon P W, Fowler J F
Br J Cancer. 1976 Oct;34(4):401-7. doi: 10.1038/bjc.1976.183.
Pre-operative X-irradiation of s.c. implanted first-generation mammary tumours in C3H mice, using either 500 rad or two fractions of 350 rad, produced no improvement in the success of surgery in causing local control or in reduction of distant metastases. The metastasis rate was just significantly higher after the two-fraction treatment of the implanted tumour than after surgical removal alone. The results are in agreement with previously published results on carcinomas and a sarcoma but contrast with those for murine lymphomas.
对C3H小鼠皮下植入的第一代乳腺肿瘤进行术前X线照射，采用500拉德或两个350拉德分次照射，在手术实现局部控制或减少远处转移的成功率方面均未取得改善。植入肿瘤接受两次分次治疗后的转移率仅比单纯手术切除后显著更高。这些结果与先前发表的关于癌和肉瘤的结果一致，但与小鼠淋巴瘤的结果形成对比。
