Maurice-Estepa L, Daudon M, Katlama C, Jouanneau C, Sazdovitch V, Lacour B, Beaufils H
Service de Biochimie A and INSERM U 423, Hôpital Necker-Enfants Malades, Paris, France.
Am J Kidney Dis. 1998 Sep;32(3):392-400. doi: 10.1053/ajkd.1998.v32.pm9740154.
Three acquired immune deficiency syndrome patients given foscarnet to treat cytomegalovirus retinitis developed renal failure with crystal deposits within the renal glomeruli. We identified these crystals as a mixture of sodium salt, calcium salt, and a mixed salt containing both sodium and calcium ions. This composition has not been previously reported. Foscarnet can complex available ionized calcium and secondarily precipitate in glomeruli. The percentage of complexing depends on calcium concentration in serum and the poor calcium salt solubility.
三名获得性免疫缺陷综合征患者接受膦甲酸钠治疗巨细胞病毒性视网膜炎后出现肾衰竭，肾小球内有晶体沉积。我们鉴定这些晶体为钠盐、钙盐以及一种同时含有钠离子和钙离子的混合盐的混合物。这种成分此前未见报道。膦甲酸钠可与游离的离子钙络合，继而在肾小球内沉淀。络合的百分比取决于血清中的钙浓度以及钙盐的低溶解度。
