Curth H O
Br J Dermatol. 1976 Oct;95(4):433-6. doi: 10.1111/j.1365-2133.1976.tb00847.x.
A man born with a unilateral epidermal naevus on the right side of the abdomen developed at puberty symmetrical benign acanthosis nigricans in the body folds. The symmetrical eruption later disappeared completely. The unilateral epidermal naevus and the symmetrical eruption showed identical histological features, i.e. those of acanthosis nigricans. At the age of 32 he developed a muco-epidermoid cancer of the left parotid gland. A decision whether the association of unilateral epidermal naevi with malignant tumours occurs with unusual frequency requires (a) a long follow-up of the patient with the unilateral naevus, (b) a differentiation of the unilateral eruption from unilateral malignant acanthosis nigricans and (c) statistical evidence.
一名出生时右侧腹部有单侧表皮痣的男子，在青春期时身体褶皱处出现了对称性良性黑棘皮病。这种对称性皮疹后来完全消失。单侧表皮痣和对称性皮疹表现出相同的组织学特征，即黑棘皮病的特征。32岁时，他患上了左腮腺黏液表皮样癌。要确定单侧表皮痣与恶性肿瘤的关联是否异常频繁发生，需要：(a) 对患有单侧痣的患者进行长期随访；(b) 将单侧皮疹与单侧恶性黑棘皮病区分开来；(c) 统计学证据。
