Suzumori Nobuhiro, Suzumori Kaoru
Department of Obstetrics and Gynaecology, Nagoya City University Medical School, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan.
Gynecol Obstet Invest. 2003;56(1):51-4. doi: 10.1159/000072694. Epub 2003 Jul 26.
Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might also be the case for CNTF levels has been published previously. The CNTF concentrations in the peritoneal fluid were measured by ELISA in 51 women with (n = 31) and without (n = 20) endometriosis. Surgery was scheduled during the proliferative or the secretory phase of the menstrual cycle. CNTF was detectable in the peritoneal fluid of 43% of the women tested. The concentrations of CNTF showed no correlation with the presence of endometriosis or the phase of the menstrual cycle. We found no evidence to suggest that CNTF is involved in the pathogenesis of pelvic endometriosis.
睫状神经营养因子（CNTF）是一种属于白细胞介素-6型细胞因子超家族的gp130神经调节细胞因子。多项证据表明，子宫内膜异位症患者腹腔液中白细胞介素-6的浓度升高。据我们所知，此前尚未发表过关于CNTF水平是否也如此的研究。通过酶联免疫吸附测定法（ELISA）测量了51例患有（n = 31）和未患有（n = 20）子宫内膜异位症的女性腹腔液中的CNTF浓度。手术安排在月经周期的增殖期或分泌期进行。在43%的受试女性的腹腔液中可检测到CNTF。CNTF的浓度与子宫内膜异位症的存在或月经周期阶段均无相关性。我们没有发现证据表明CNTF参与盆腔子宫内膜异位症的发病机制。
