Spinarová L, Toman J, Pospísilová J, Souĉek M, Kára T, Stejfa M
1st Internal Department, Masaryk University, Brno, Czech Republic.
Int J Cardiol. 1998 Aug;65(3):227-32. doi: 10.1016/s0167-5273(98)00116-8.
Correlation of five humoral markers with laboratory, echocardiographic and right heart catheterization parameters in patients with chronic heart failure.
29 patients, heart failure NYHA II and III, ejection fraction below 40% with coronary artery disease or dilated cardiomyopathy.
evaluation of thromboxane, prostaglandin F (PGF), tumor necrosis factor (TNF) alpha, endothelin-1 and big endothelin rest levels and their correlation with: (1) laboratory parameters: Sodium, urea, creatinine, fibrinogen, (2) chest X-ray: cardiothoracic index (CTI), pulmonary congestion, (3) right heart catheterization parameters at rest, hand-grip and bicycle ergometry: mean pulmonary artery pressure (AP), wedge pressure (WP), systemic and pulmonary vascular resistance (SVR, PVR) and cardiac index (CI), (4) echocardiographic parameters at rest, hand-grip and bicycle ergometry: end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), mitral flow E/A, filling period of left ventricle and time of duration of mitral regurgitation.
No correlation was found between thromboxane, prostaglandin F and tumor necrosis factor alpha with the above mentioned parameters. Endothelin-1 level correlated with E/A, PVR and MPA at rest and at hand-grip. Big endothelin level correlated with EDV and ESV, AP, WP and SVR at rest and at both types of exercise. The highest correlation was between big endothelin and rest AP (r=0.79), rest WP (r=0.78) and CTI (r=0.58), all P<0.01.
Big endothelin and partly endothelin-1 levels showed a close correlation with some parameters used for the evaluation of chronic heart failure severity.
探讨慢性心力衰竭患者五种体液标志物与实验室检查、超声心动图及右心导管检查参数之间的相关性。
29例纽约心脏病协会（NYHA）心功能Ⅱ级和Ⅲ级的心力衰竭患者，射血分数低于40%，病因包括冠状动脉疾病或扩张型心肌病。
评估血栓素、前列腺素F（PGF）、肿瘤坏死因子（TNF）α、内皮素-1和大内皮素的静息水平，并分析它们与以下各项的相关性：（1）实验室参数：钠、尿素、肌酐、纤维蛋白原；（2）胸部X线：心胸指数（CTI）、肺淤血情况；（3）静息、握力试验和踏车运动时的右心导管检查参数：平均肺动脉压（AP）、楔压（WP）、体循环和肺循环血管阻力（SVR、PVR）以及心脏指数（CI）；（4）静息、握力试验和踏车运动时的超声心动图参数：舒张末期容积（EDV）、收缩末期容积（ESV）、射血分数（EF）、二尖瓣血流E/A比值、左心室充盈期以及二尖瓣反流持续时间。
未发现血栓素、前列腺素F和肿瘤坏死因子α与上述参数之间存在相关性。内皮素-1水平与静息及握力试验时的E/A比值、PVR和MPA相关。大内皮素水平与静息及两种运动状态下的EDV、ESV、AP、WP和SVR相关。大内皮素与静息AP（r = 0.79）、静息WP（r = 0.78）和CTI（r = 0.58）之间的相关性最强，均P < 0.01。
大内皮素水平以及部分内皮素-1水平与用于评估慢性心力衰竭严重程度的某些参数密切相关。
