Kaplan E J, Caputo T A, Shen P U, Sassoon R I, Soslow R A
Cornell University Medical College, New York, New York, USA.
Gynecol Oncol. 1998 Aug;70(2):289-94. doi: 10.1006/gyno.1998.5046.
We report an occult primary papillary serous carcinoma of the endocervix that was encountered in a woman whose mother and identical twin sister died of papillary serous carcinomas (PSCs) of the peritoneum and ovary, respectively.
The medical records and the histologic material belonging to the patient, her sister, and her mother were reviewed.
The cervical PSC was histologically similar to the peritoneal and ovarian carcinomas. The patient has recurred with peritoneal carcinomatosis 24 months following surgery and postoperative radiotherapy and chemotherapy.
Primary papillary serous carcinoma of the cervix is a very rare adenocarcinoma variant; there have been approximately 30 such cases reported, and, to our knowledge, this is the first documented case of familial peritoneal/ovarian/uterine papillary serous carcinoma. The prophylaxis achieved through bilateral oophorectomy in individuals with a family history of ovarian cancer does not address the risk of PSCs arising in the uterus, cervix, or peritoneum.
我们报告了一例宫颈隐匿性原发性浆液性乳头状癌，该病例发生在一名女性身上，其母亲和同卵双胞胎姐妹分别死于腹膜和卵巢的浆液性乳头状癌（PSC）。
回顾了该患者及其姐妹和母亲的病历及组织学资料。
宫颈PSC在组织学上与腹膜和卵巢癌相似。该患者在手术及术后放疗和化疗24个月后出现腹膜癌转移复发。
宫颈原发性浆液性乳头状癌是一种非常罕见的腺癌变体；据报道约有30例此类病例，据我们所知，这是首例有文献记载的家族性腹膜/卵巢/子宫浆液性乳头状癌病例。对有卵巢癌家族史的个体进行双侧卵巢切除术所实现的预防措施并不能消除子宫、宫颈或腹膜发生PSC的风险。
