服用氯氮平（利培酮）后发生急性泛发性脓疱性皮病。首例病例
[Acute generalized exanthematic pustulosis after intake of clozapine (leponex). First case] case].
作者信息
Bosonnet S, Dandurand M, Moati L, Guillot B
机构信息
Service de Dermatologie, CHU de Nîmes.
出版信息
Ann Dermatol Venereol. 1997;124(8):547-8.
BACKGROUND
Acute generalized exanthematic pustulosis is a severe adverse drug reaction which occurs after taking antibiotics. Rare cases implicating psychotrops have been observed.
CASE REPORT
A 71-year old women with schizophrenia was given closapine for six weeks when she developed an erythematopustular skin reaction and fever typical of acute generalized exanthematic pustulosis. The skin disease regressed one week after withdrawing clozapine.
DISCUSSION
This is the first case of acute generalized exanthematic pustulosis observed after taking the neuroleptic drug, clozapine, used in severe schizophrenia.
背景
急性泛发性脓疱病是服用抗生素后发生的一种严重药物不良反应。已观察到罕见的涉及精神药物的病例。
病例报告
一名71岁的精神分裂症女性服用氯氮平六周后，出现了急性泛发性脓疱病典型的红斑脓疱性皮肤反应和发热。停用氯氮平一周后皮肤病消退。
讨论
这是首例在使用用于严重精神分裂症的抗精神病药物氯氮平后观察到的急性泛发性脓疱病病例。
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