Holmes G F, Eisele D W, Rosenthal D, Westra W H
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-6417, USA.
Diagn Cytopathol. 1998 Sep;19(3):221-5. doi: 10.1002/(sici)1097-0339(199809)19:3<221::aid-dc14>3.0.co;2-g.
Prostate-specific antigen (PSA) is secreted by both normal and neoplastic acinar cells of the prostate gland, and the immunohistochemical detection of PSA is widely accepted as an excellent method for confirming the prostatic origin of metastatic tumor implants in men with prostate cancer. Less recognized is the observation that certain nonprostatic tissues and their neoplastic counterparts also secrete PSA. As one example, salivary gland ducts and certain salivary gland neoplasms have been reported to be immunoreactive for PSA. Potentially, this nonspecificity could be a diagnostic pitfall when using immunoperoxidase on fine-needle aspiration (FNA) biopsy specimens to differentiate metastatic prostate cancer from primary salivary gland tumors. We report on a case where strong PSA immunoreactivity of a parotid oncocytoma led to its confusion with metastatic prostate cancer.
前列腺特异性抗原（PSA）由前列腺的正常腺泡细胞和肿瘤性腺泡细胞分泌，PSA的免疫组化检测作为一种确认前列腺癌男性患者转移瘤种植的前列腺来源的极佳方法，已被广泛接受。较少被认识到的是，某些非前列腺组织及其肿瘤对应物也分泌PSA。例如，涎腺导管和某些涎腺肿瘤已被报道对PSA呈免疫反应性。在使用免疫过氧化物酶对细针穿刺（FNA）活检标本进行检测以区分转移性前列腺癌和原发性涎腺肿瘤时，这种非特异性可能会成为诊断陷阱。我们报告了一例腮腺嗜酸性细胞瘤PSA免疫反应性强，导致其与转移性前列腺癌混淆的病例。
