Texas A&M University School of Dentistry, Dallas, USA.
Baylor University Medical Center, Dallas, USA.
Head Neck Pathol. 2024 Nov 30;18(1):126. doi: 10.1007/s12105-024-01730-6.
Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.
A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.
Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.
Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.
嗜酸细胞瘤是一种主要的良性上皮性肿瘤，占唾液腺肿瘤的比例不到 2%，复发率低。
对已发表的嗜酸细胞瘤病例报告和病例系列进行了系统回顾。从不同的数据库中进行了搜索，以确定从 1956 年到 2024 年的文章。所包括的变量包括性别、年龄、症状、诊断前的时间、腺体类型、组织学特征、特殊或免疫组织化学评估、治疗、随访、复发以及与医疗状况或综合征的关系。
在报告的 147 例病例中，53.1%的患者为女性，46.9%的患者为男性。平均年龄为 58.7 岁，平均大小为 2.3 厘米。最常见的临床表现为肿胀（92.6%），66.7%的患者无症状。最常受影响的腺体是腮腺，占 66%，下颌下腺占 23.3%，下颌下腺占 36.7%。最常用的特殊染色是磷钨酸-苏木精（PTAH），其次是与 PAS 结合，不结合或结合唾液酶，占 26.6%。切除活检是最常见的治疗方法，占 38.1%，其次是腮腺浅叶切除术，占 32.7%。平均随访时间为 34.7 个月。双侧嗜酸细胞瘤占 4.8%，女性与男性的比例为 6:1。复发率为 2.7%，与 Birt-Hogg-Dube（BHD）综合征的关联为 8.2%。
唾液腺嗜酸细胞瘤是一种罕见的上皮性肿瘤，临床表现无特异性。细胞学检查可怀疑诊断，组织学检查可确诊。病变具有惰性的临床过程，大多数报道的病例没有复发。双侧嗜酸细胞瘤与女性之间似乎存在关联，与 BHD 之间也存在低但有趣的关联。总的来说，这篇综述有助于更好地突出这种罕见良性肿瘤的特征。
