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利用着色性干皮病细胞核提取物切除5,6 - 二羟基 - 二氢胸腺嘧啶类型的紫外线和γ射线产物。

Excision of ultraviolet and gamma ray products of the 5,6-dihydroxy-dihydrothymine type by nuclear preperations of xeroderma pigmentosum cells.

作者信息

Hariharan P V, Cerutti P A

出版信息

Biochim Biophys Acta. 1976 Oct 18;447(3):375-8. doi: 10.1016/0005-2787(76)90060-5.

DOI:10.1016/0005-2787(76)90060-5
PMID:974131
Abstract

Monomeric products of the 5,6-dihydroxy-dihydrothymine type are produced in the DNA by both ultraviolet and ionizing radiations. The capacity of nuclear preparations from normal and Xeroderma pigmentosum (XP) cells (Complementation groups A, B, C and D) to excise such products from ultraviolet or gamma-irradiated T7DNA was comparable and was independent of radiation induced strand breaks.

摘要

5,6 - 二羟基 - 二氢胸腺嘧啶类型的单体产物可由紫外线和电离辐射在DNA中产生。来自正常细胞和着色性干皮病(XP)细胞(互补组A、B、C和D)的核提取物从紫外线或γ射线照射的T7DNA中切除此类产物的能力相当,且与辐射诱导的链断裂无关。

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