共济失调毛细血管扩张症成纤维细胞制剂对γ射线诱导的胸腺嘧啶损伤的切除作用
Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts.
作者信息
Remsen J F, Cerutti P A
出版信息
Mutat Res. 1977 Apr;43(1):139-45. doi: 10.1016/0027-5107(77)90138-5.
PMID:865488
Abstract
The capacity of whole cell sonicates of skin fibroblasts of normal individuals and patients with the autosomal recessive disease Ataxia telangiectasia (AT) to remove aerobic gamma-ray products of the 5,6-dihydroxydihydrothymine type (tgamma02) from exogenous DNA substrates was investigated. All four AT strains (AT CRL 1312, AT CRL 1343, AT GM 367, AT 4BI) possessed normal capabilities to excise tgamma02 from irradiated bacteriophage DNA and irradiated chromatin isolated from normal and AT-skin fibroblasts.
摘要
研究了正常个体以及患有常染色体隐性疾病共济失调毛细血管扩张症（AT）患者的皮肤成纤维细胞全细胞超声裂解物从外源DNA底物中去除5,6 - 二羟基二氢胸腺嘧啶类型（tgamma02）的需氧γ射线产物的能力。所有四株AT菌株（AT CRL 1312、AT CRL 1343、AT GM 367、AT 4BI）都具备从经辐照的噬菌体DNA以及从正常和AT皮肤成纤维细胞分离出的经辐照染色质中切除tgamma02的正常能力。
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