Filippi M, Rocca M A, Comi G
MS Biosignal Analysis Center, Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
J Neurol Sci. 1998 Aug 14;159(2):162-5. doi: 10.1016/s0022-510x(98)00162-2.
We evaluated whether new multiple sclerosis (MS) lesions with variable durations of enhancement have different magnetization transfer ratios (MTR) at the time of their appearance. We scanned ten patients with relapsing-remitting MS every four weeks on four occasions. During each of the monthly sessions, we obtained dual echo, MT and T1-weighted scans. Five minutes after gadolinium-DTPA (Gd) injection, another T1-weighted scan was obtained. We measured the MTR of new enhancing lesions on co-registered quantitative MTR images. During the three-month follow up, 54 new enhancing lesions were seen with a mean MTR value of 33.6% (SD=7.8%). The mean MTR values were 35.3% (SD=7.0%) for lesions enhancing on only one scan and 29.3% (SD=8.6%) for those enhancing on at least two consecutive scans (P=0.01). These results suggest that enhancing lesions in MS have heterogeneous pathological substrates, which may be associated with different durations of the enhancing phase.
我们评估了具有不同强化持续时间的新发多发性硬化（MS）病灶在出现时是否具有不同的磁化传递率（MTR）。我们对10例复发缓解型MS患者进行了4次扫描，每次间隔4周。在每个月度检查期间，我们获取了双回波、MT和T1加权扫描图像。注射钆喷酸葡胺（Gd）5分钟后，又获取了一次T1加权扫描图像。我们在配准后的定量MTR图像上测量新发强化病灶的MTR。在3个月的随访期间，共观察到54个新发强化病灶，平均MTR值为33.6%（标准差=7.8%）。仅在一次扫描中强化的病灶平均MTR值为35.3%（标准差=7.0%），而在至少连续两次扫描中强化的病灶平均MTR值为29.3%（标准差=8.6%）（P=0.01）。这些结果表明，MS中的强化病灶具有异质性病理基础，这可能与强化期的不同持续时间有关。
