Satomi K, Satoh T, Kyotani S, Fukushima S, Okano Y, Nakanishi N, Kunieda T
Nihon Kokyuki Gakkai Zasshi. 1998 May;36(5):421-7.
Pulmonary hypertension is a progressive disease for which no effective therapy has been found. Short-team treatment with alprostadil alfadex (PGE 1) can improve hemodynamics but the effects of long-term treatment have not been reported. We administered intravenous PGE 1 to 16 patients with pulmonary hypertension for 4 weeks in addition to conventional therapy. Hemodynamic and symptomatic effects were evaluated. The infusion was interrupted in 7 patients (44%) because of fever and an increase in levels of C-reactive protein in serum. In the remaining 9 patients, the drug lowered pulmonary artery pressure and resistance, and imareased cardiac output significantly in 7 patients. PGE 1 can improve hemodynamics and relieve symptoms in patients with pulmonary hypertension, barring severe side effects.
肺动脉高压是一种尚未找到有效治疗方法的进行性疾病。前列地尔脂微球载体制剂（PGE1）短期治疗可改善血流动力学，但长期治疗的效果尚未见报道。除常规治疗外，我们对16例肺动脉高压患者静脉输注PGE1共4周，评估其血流动力学和症状改善情况。7例患者（44%）因发热和血清C反应蛋白水平升高而中断输注。其余9例患者中，该药物降低了肺动脉压力和阻力，7例患者的心输出量显著增加。排除严重副作用，PGE1可改善肺动脉高压患者的血流动力学并缓解症状。
