Nakazato Y, Shimazu K, Tamura N, Shimazu T, Hamaguchi K
Department of Neurology, Saitama Medical School.
Rinsho Shinkeigaku. 1998 Apr;38(4):336-8.
Serum urate and sodium concentrations were measured in 23 patients with acute viral and bacterial meningitis. Serum urate level was 3.0 +/- 0.2 mg/dl (mean +/- S.D.) (3.6 +/- 1.2 mg/dl in male and 2.5 +/- 0.9 mg /dl in female) on admission, but gradually elevated with improvements of meningitis. It turned to 4.8 +/- 0.2 mg/dl after recovery, and the value on admission was significantly lower than that after recovery (p < 0.0001). Serum sodium level was 137.6 +/- 2.9 mEq/l on admission and 139.7 +/- 2.7 mEq/l after recovery; also lower in the former (p < 0.01). These results show that patients develop transient hypouricemia, which may be explained by SIADH (syndrome of inappropriate secretion of ADH), although SIADH is subclinical in most cases of meningitis.
对23例急性病毒性和细菌性脑膜炎患者测定了血清尿酸盐和钠浓度。入院时血清尿酸盐水平为3.0±0.2mg/dl（均值±标准差）（男性为3.6±1.2mg/dl，女性为2.5±0.9mg/dl），但随着脑膜炎病情改善而逐渐升高。恢复后升至4.8±0.2mg/dl，入院时的值显著低于恢复后的水平（p<0.0001）。入院时血清钠水平为137.6±2.9mEq/l，恢复后为139.7±2.7mEq/l；前者也较低（p<0.01）。这些结果表明，患者会出现短暂性低尿酸血症，这可能由抗利尿激素分泌失调综合征（SIADH）来解释，尽管在大多数脑膜炎病例中SIADH为亚临床状态。
