Yamasaki K, Nakano M, Kawahata T, Mori H, Otake T, Ueba N, Oishi I, Inami R, Yamane M, Nakamura M, Murata H, Nakanishi T
Osaka Prefectural Institute of Public Health, Japan.
Biol Pharm Bull. 1998 Aug;21(8):829-33. doi: 10.1248/bpb.21.829.
The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha x piperita "grapefruit mint," Mentha x piperita var. crispa, Ocimum basilicum cv "cinnamon," Perilla frutescens var. crispa f. viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16 microg/ml). The active components in the extract samples were found to be water-soluble polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cells with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.
对唇形科芳香草药的抗HIV-1活性进行了体外评估。从46种草药物种中获取的51个样品中的45种提取物对MT-4细胞中HIV-1诱导的细胞病变效应显示出显著的抑制作用。特别是，香蜂草、薄荷属的“葡萄柚薄荷”、皱叶薄荷、“肉桂”罗勒、皱叶紫苏绿色变型、夏枯草亚洲亚种和山地风轮菜的水提取物显示出强大的抗HIV-1活性（半数有效剂量为16微克/毫升）。提取物样品中的活性成分被发现是水溶性极性物质，而非精油等非极性化合物。此外，这些水提取物抑制了Molt-4细胞在有或无HIV-1感染的共培养中的巨细胞形成，并显示出对HIV-1逆转录酶的抑制活性。
