Goldstein R E, Marks S L, Kass P H, Cowgill L D
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616-8734, USA.
J Am Vet Med Assoc. 1998 Sep 15;213(6):826-8.
To determine the prevalence of hypergastrinemia in cats with naturally developing chronic renal failure (CRF) and the correlation between gastrin concentration in plasma and severity of CRF.
Cohort study.
30 cats with naturally developing CRF and 12 clinically normal control cats.
Gastrin concentrations in plasma were determined by double-antibody radioimmunoassay of blood samples obtained from cats after food was withheld 8 hours. Concentrations were compared, using a nonparametric Kruskal-Wallis ANOVA.
18 cats with CRF had high gastrin concentrations (median, 45 pg/ml; range, < 18 to > 1,333 pg/ml), compared with those for control cats (< 18 pg/ml). Prevalence of hypergastrinemia increased with severity of renal insufficiency. Three of 9 cats with mild CRF, 6 of 11 cats with moderate CRF, and 9 of 10 cats with severe CRF had high gastrin concentrations. Gastrin concentrations were significantly different between control cats and cats with CRF, regardless of disease severity.
The potential role of high concentrations of gastrin on gastric hyperacidity, uremic gastritis, bleeding from the gastrointestinal tract, and associated clinical signs of hypergastrinemia (e.g., anorexia and vomiting) may justify use of histamine2-receptor antagonists or proton pump inhibitors to suppress gastric acid secretion in cats with CRF that have these clinical signs.
确定自然发生慢性肾衰竭（CRF）的猫中高胃泌素血症的患病率，以及血浆胃泌素浓度与CRF严重程度之间的相关性。
队列研究。
30只自然发生CRF的猫和12只临床正常的对照猫。
对禁食8小时后的猫采集血样，采用双抗体放射免疫分析法测定血浆胃泌素浓度。使用非参数Kruskal-Wallis方差分析比较浓度。
与对照猫（<18 pg/ml）相比，18只CRF猫的胃泌素浓度较高（中位数为45 pg/ml；范围为<18至>1333 pg/ml）。高胃泌素血症的患病率随肾功能不全的严重程度增加。9只轻度CRF猫中有3只、11只中度CRF猫中有6只、10只重度CRF猫中有9只胃泌素浓度较高。无论疾病严重程度如何，对照猫和CRF猫之间的胃泌素浓度均有显著差异。
高浓度胃泌素对胃酸过多、尿毒症性胃炎、胃肠道出血以及高胃泌素血症相关临床症状（如厌食和呕吐）的潜在作用，可能说明对于出现这些临床症状的CRF猫，使用组胺2受体拮抗剂或质子泵抑制剂抑制胃酸分泌是合理的。
Zotero 插件