新型支气管扩张剂异丁特罗（特布他林的前体药物）经口服和皮下给药对正常受试者的循环系统影响。
Circulatory effects of oral and subcutaneous administration in normal subjects of a new bronchodilator, ibuterol, a pro-drug to terbutaline.
作者信息
Höglund E, Westling H, White T
出版信息
Br J Pharmacol. 1976 Sep;58(1):43-6. doi: 10.1111/j.1476-5381.1976.tb07691.x.
Abstract
1 The di-isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different. 2 By mouth, ibuterol acted more rapidly, and was 2-3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline. 3 Ibuterol can be regarded as a pro-drug, which in itself has little activity, but which can be made active in the body.
摘要
- 将特布他林的二异丁酯（异丙喘宁）皮下注射和口服给予健康志愿者，并将其对心率、动脉血压和心电图的影响与特布他林本身的影响进行比较。这两种物质的作用在性质上相同，但在数量上不同。2. 口服时，异丙喘宁起效更快，活性是特布他林的2至3倍。肌肉注射后，异丙喘宁引起的局部血流增加比特布他林少。3. 异丙喘宁可被视为一种前体药物，其本身活性很小，但在体内可转化为有活性的物质。
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Comparison of intravenous ibuterol (KWD 2058), a new bronchodilator, and terbutaline.
Eur J Clin Pharmacol. 1977 Jul 19;11(6):429-33. doi: 10.1007/BF00562933.
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2
Pharmacological properties of 1-(3'5'-diisobutyryloxy-phenyl)-2-(t-butylamino)-ethanolhydrochloride (KWD 2058), a new sympathomimetic bronchodilator.新型拟交感神经支气管扩张剂1-(3',5'-二异丁酰氧基-苯基)-2-(叔丁基氨基)-乙醇盐酸盐（KWD 2058）的药理学特性
Acta Pharmacol Toxicol (Copenh). 1974 Jul;35(1):76-90. doi: 10.1111/j.1600-0773.1974.tb00727.x.
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Br J Pharmacol. 1971 Oct;43(2):389-402.
4
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Acta Med Scand Suppl. 1970;512:25-32. doi: 10.1111/j.0954-6820.1970.tb05286.x.
5
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