Hipkiss A R
Molecular Biology and Biophysics Group, King's College London, Strand, UK.
Int J Biochem Cell Biol. 1998 Aug;30(8):863-8. doi: 10.1016/s1357-2725(98)00060-0.
Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer's disease.
肌肽（β-丙氨酰-L-组氨酸）除了具有抗氧化和清除自由基的作用外，还具有保护功能。它能延长培养的人成纤维细胞的寿命，杀死转化细胞，保护细胞免受醛类和淀粉样肽片段的侵害，并在体外抑制蛋白质糖基化（交联、羰基和晚期糖基化终末产物的形成）以及DNA/蛋白质交联。肌肽是一种醛清除剂，可能是脂褐素（老年色素）的前体，也是糖尿病并发症、动脉粥样硬化和阿尔茨海默病的潜在调节剂。
