Auer C, Herbort C P
La Source Eye Center, and Hôpital Jules Gonin, Department of Ophthalmology, University of Lausanne, Switzerland.
Am J Ophthalmol. 1998 Sep;126(3):471-6. doi: 10.1016/s0002-9394(98)00119-6.
To determine choroidal involvement in posterior scleritis by examining indocyanine green angiographic features.
Indocyanine green angiography was performed according to a standard uveitis angiographic protocol in eight consecutive patients with posterior scleritis. Indocyanine green angiography data were compared to fundus color photographs, red-free photographs, and fluorescein angiography.
The principal indocyanine green angiographic feature was diffuse zonal choroidal indocyanine green hyperfluorescence in the intermediate (+/-10 minutes) and late (+/-40 minutes) phases of angiography present in all eight patients who regressed in response to anti-inflammatory therapy. In four patients (two with massive subretinal exudation), additional fluorescing pinpoints were present in the zonal hyperfluorescent areas. Additional features included irregular delayed choroidal perfusion (five of eight patients)--irregularly distributed dark dots that were present up to the intermediate phase and becoming isofluorescent in the late phase that gave a mottled aspect to the choroid--and enlargement of draining choroidal veins. In bilateral patients, clinical features and indocyanine green angiography signs were roughly symmetric.
In posterior scleritis, indocyanine green angiography allowed us to identify areas of choroidal hyperfluorescence, possibly indicating areas of maximal inflammatory activity, and demonstrated regression of hyperfluorescence in response to therapy. Indocyanine green angiography was useful in assessing the extent of choroidal involvement and will probably serve as one of the follow-up parameters for disease evolution and response to therapy.
通过检查吲哚菁绿血管造影特征来确定脉络膜在后巩膜炎中的受累情况。
按照标准葡萄膜炎血管造影方案，对连续8例后巩膜炎患者进行吲哚菁绿血管造影。将吲哚菁绿血管造影数据与眼底彩色照片、无赤光照片及荧光素血管造影进行比较。
吲哚菁绿血管造影的主要特征是在血管造影的中期（±10分钟）和晚期（±40分钟）出现弥漫性带状脉络膜吲哚菁绿高荧光，所有8例对抗炎治疗有反应的患者均有此表现。4例患者（2例有大量视网膜下渗出）在带状高荧光区域出现额外的荧光小点。其他特征包括不规则延迟脉络膜灌注（8例患者中的5例）——不规则分布的暗点，直至中期仍存在，晚期变为等荧光，使脉络膜呈现斑驳外观——以及引流脉络膜静脉增粗。在双侧患病的患者中，临床特征和吲哚菁绿血管造影征象大致对称。
在后巩膜炎中，吲哚菁绿血管造影使我们能够识别脉络膜高荧光区域，这可能提示最大炎症活动区域，并显示出治疗后高荧光的消退。吲哚菁绿血管造影有助于评估脉络膜受累程度，可能会成为疾病进展及对治疗反应的随访参数之一。
